GnRH peripherally modulates nociceptor functions, exacerbating mechanical pain
The function of peripheral nociceptors, the neurons that relay pain signals to the brain, fr5947 are frequently tuned by local and systemic modulator substances.In this context, neurohormonal effects are emerging as an important modulatory mechanism, but many aspects remain to be elucidated.Here we report that gonadotropin-releasing hormone (GnRH),